A New Congenital Abnormal Fibrinogen Ise Characterized by the Replacement of BP Glycine - 15 by Cysteine
نویسندگان
چکیده
A new case of heterozygous dysfibrinogenemia characterized by the replacement of NH,-terminal amino acid of fibrin p-chain was found in a 50-year-old man. Despite a prolonged thrombin time, the propositus‘ fibrinogen had a normal reptilase time with the normal release of fibrinopeptide A. Release of fibrinopeptide B by thrombin was strongly affected, but a very high concentration of thrombin almost completely released fibrinopeptide B with a normal elution pattern on reversed-phase high performance liquid chromatography (HPLC). Lysylendopeptidase-cleavage of purified Bp-chains analyzed on HPLC showed the decrease of one peptide compared with the normal and the appearance of an abnormal peptide peak. These peptides were treated with thrombin and further separated on HPLC. Amino acid se-
منابع مشابه
A new congenital abnormal fibrinogen Ise characterized by the replacement of B beta glycine-15 by cysteine.
A new case of heterozygous dysfibrinogenemia characterized by the replacement of NH2-terminal amino acid of fibrin beta-chain was found in a 50-year-old man. Despite a prolonged thrombin time, the propositus' fibrinogen had a normal reptilase time with the normal release of fibrinopeptide A. Release of fibrinopeptide B by thrombin was strongly affected, but a very high concentration of thrombin...
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